Symptoms and Side Effects

Skin Problems

A person using a dry brush on her legs while sitting on the edge of a bathtub

Skin Problems from Cancer Treatment

Your skin may react to treatment in ways that are visible or uncomfortable. While these changes can be upsetting, many are expected and will fade over time. Others may be more serious and require quick attention. Understanding what’s typical—and when to call your care team—can help you feel more confident and in control.

A person standing in front of the shower using a purple towel to dry off

Minor Skin Changes

These are common during treatment and usually do not require medical intervention. Symptoms may include:

  • Mild itching, dryness, redness, or peeling
  • Sensitivity to the sun (can occur in all skin tones)
  • Hyperpigmentation—dark patches that may appear:
    • Around your joints
    • Under your nails
    • In your mouth
    • Along the veins used for chemo
    • Under tape or dressings
    • In your hair

Major Skin Changes

These symptoms could indicate a more serious issue and should be reported to your cancer team:

  • IV site reactions: Burning or pain where you receive chemotherapy through a vein
  • Moderate-to-severe itching, dryness, redness, or peeling
  • Allergic reactions: If you notice any of the following along with wheezing or trouble breathing:
    • Sudden, severe itching
    • Rash
    • Hives
  • Radiation recall: Red, painful, or blistered skin in the area where you had radiation

At-Home Skin Care Solutions

Sun Care During Treatment

Skin sensitivity can increase during cancer treatment. Protect yourself by:

  • Staying out of direct sunlight, especially between 10 a.m. and 4 p.m.
  • Using sunscreen with SPF 15 or higher (zinc oxide ointments may also help)
  • Applying SPF 15+ lip balm to keep lips protected
  • Wearing long-sleeved, light-colored cotton clothing and a wide-brimmed hat
  • Avoiding tanning beds altogether

Coping with Radiation Recall

If you’re experiencing skin symptoms in a previously radiated area:

  • Keep the area covered and protected from sunlight
  • Avoid tight or scratchy clothing—opt for soft cotton underwear and shirts
  • Use a cool, damp cloth to soothe discomfort

If you’re unsure whether a skin change is normal or requires medical attention, don’t hesitate to reach out to your care team. They can help determine the best way to address your skin concerns and ensure your treatment stays on track.