Hand-Foot Syndrome
What Is Hand-Foot Syndrome
Hand-foot syndrome is a potential side effect of certain chemotherapy and targeted therapies. It affects the skin on the palms of your hands and soles of your feet, which can interfere with your daily activities. Symptoms may include:
- Pain, tenderness, or sensitivity
- Redness and swelling
- Tingling or burning sensations
- Dryness or peeling skin
- Cracks, blisters, or sores (in more severe cases)
Fortunately, these effects usually improve once treatment is paused or your medication dose is adjusted.
Caring for Yourself at Home: Prevention Tips
Start early with gentle care to reduce the likelihood of symptoms and protect your skin during treatment.
Moisturize Often
Use thick creams (e.g. urea-based) or ointments like Bag Balm, Udderly Smooth, or Aquaphor. Apply gently—avoid rubbing or massaging too firmly.
Avoid Hot Water
Take cool showers and baths. Rinse dishes in lukewarm—not hot—water.
Limit Skin Exposure
Avoid extended time in water (like doing dishes), sun exposure, and sources of heat such as saunas.
Reduce Friction and Pressure
Skip high-impact or high-friction activities like jogging, tennis, or using hand tools.
Use Protective Gear
Wear soft slippers with non-slip soles and loose-fitting clothes and shoes.
Avoid Irritants
Limit contact with household cleaning products like laundry detergents—wear gloves if needed.
Medications
Talk with your doctor about medications (e.g. topical diclofenac).
Managing Symptoms
If symptoms begin, treat them as soon as they show up.
- Cool affected areas. Apply ice packs or soak hands and feet in cool water for about 15 minutes at a time. Always place a towel between the ice and your skin.
- Keep moisturizing. Reapply thick moisturizers frequently.
- Talk with your doctor about medications:
- Topical corticosteroids to reduce inflammation.
- Pain relief creams or patches to help manage discomfort.
- Oral medications like ibuprofen or naproxen may help with inflammation or pain.
When to Call Your Care Team
Reach out right away if:
- Your skin is peeling, blistering, or bleeding.
- Swelling is severe or worsening.
- Symptoms are making it hard to walk, work, or carry out daily tasks.
